Special solution for the continuous release of active ingredients
For many patients, the regular intake of drugs is an enormous challenge in coping with their daily routines. The Israeli company Intec Pharma has addressed this problem by developing the Accordion Pill® platform.
From the outside, the Accordion Pill® looks like a conventional capsule, but inside it contains a small, folded "gastro retentive dosage form", or GRDF for short. The GRDF consists of the active substance and several layers of biodegradable polymeric films whose folding is reminiscent of the musical instrument. After oral intake, the capsule dissolves in the stomach. The GRDF unfolds and releases the active ingredient continuously over a period of eight to twelve hours.
From manual processes to the high-performance line
Originally, Intec Pharma started to manufacture the Accordion Pill® with manual processes. They were the basis for both the laboratory system developed by Harro Höfliger and today's high-performance line, which, with ten tracks, enables an output of up to 360 products per minute. The centerpiece of the line is the PMK, a production platform for web processing, where the different layers of the GRDF are joined together. In several folding stations, the GRDFs are folded into a compact format before encapsulation on a Modu-C machine. The line is completed with the Accura-C, a capsule weighing system for quality assurance. This guarantees consistently high production quality - even when it comes to complex customized solutions.